Gd2(CO3)3∶Eu@SiO2@APTES磁性-荧光双功能核壳微球的制备与性能.pdf

第31卷第6期
元机化学学报
Vol 31 No6
2015年6月
CHINESE JOURNAL OF INORGANIC CHEMISTRY
1125-1130
Gd(CO3)3:Eu@SiO2@ APTES磁性-荧光双功能
核壳微球的制备与性能
吴燕利1徐贤柱2文佳1肖强*1李永绣*3
(江西科技师范大学有机功能分子研究所,南昌330013
(江西师范大学生命学院,南昌33002)
(南昌大学化学学院,南昌30031)
摘要:采用尿素均相沉淀法和 Steber Y法制备了氨基化SiO2修饰的Gd(CO3)Eu颀磁性一荧光双功能微球。用扫描电镜SEM)、红
外光谱(R)、X-射线粉术行射(XRD)等测试手段对徽球的结构和颗粒特征进行了分析。结果表明:徽球为核壳结构,其Gd(CO)
Eu核平均直径为150nm左右,SiO2壳层的厚度大约为30nm,分散性良好。磁性测试显示微球拥有良好的顺磁性,荧光光谱表
明,在396nm紫外光激发下,徽球在613mm发射较强荧光,属于Fu2的特征发射,同时徽球能成功标记NCIH460肺癌细胞,
MTT毒性测试表明该法制备的双功能微球在100-400g·ml4的浓度范围内无華,表明其在生物应用方面的潜在应用价值。
关键词:顺磁性;荧光;双功能徴球;核壳结构;尿素均相沉淀法
中图分类号:0614.338文献标识码:A文章编号:1001-4861(2015)06-1125-06
DOL:10.11862/CJIC.2015.154
Synthesis and Properties of Paramagnetic-fluorescent
Gd (C03 Eu@Si02 @ APTES Core-shell Structured Microspheres
WU Yan-li! XU Xian-zhu? WEN Jia XIAO Qiang LI Yong-xiu"
(ian xi ey Laboratoy of rgani Chemist iangxi Sce ce and Technog omd Neri Nnchng330013,China
College of Life Science, iangxi Normal University, Nanchang 330022, China)
(College of Chemistry, Nanchang Universtiy, Nanchang 330031, China)
Abstract: Monodisperse core-shell structured Gd ( C Eu(@Si0@APES microsphere was successfully prepare
via the steber method by coating a layer of silica on the surface of Gd / C03) Eu microspheres which derived from
a simple urea assisted coprecipitation method. Their structural, optical and magnetic properties were investigated
using SEM, TEM, XRD, FTIR, P, and MPMS. The results indicated that the microspheres with general 30 nm
shell thickness and 150 nm core size has spherical morphology with smooth surface and narrow size distribution
The paramagnetic property of the synthesized Gd(C03) Eu(@Sio @APTES microspheres were confirmed with its
linear hysteresis plot (M-H). The synthesized microspheres can enter into living cancer cells and emit orange-red
luminescence light due to the -F2 transition of the Eu* ions, and Gd(CO), Eu@Si02@APTES microspheres
showed no cell cytotoxicity or adverse affect on kidney cell growth under high dose up to 400 ugml". Therefore
Gd (C03) Eu@Sio @APTES microspheres provides the dual modality of optical and magnetic resonance imaging
Key words: paramagnetic; fluorescent; bifunctional microsphere; core-shell structure; urea assisted coprecipitation method
收稿目期:2014-12-03。收修改稿日期:2015-02-09。
江西省教育厅一般项日(o.G14578,G.J13216),江西省科技支撑项目(No.20142BBF60003)资助
“通讯联系人。-mail:wanny118(@126.com,yxi@ncu.eulu.cn;会员登记号:S06NS032M1204.