早期免疫营养对重型颅脑损伤患者营养状况及免疫功能的影响.pdf

Guangxi Medical Journal, Mar. 2014, Vol 36, No.3
早期免疫营养对重型颅脑损伤患者营养状况及免疫功能的影响
邹天雷赵永茂
(大理学院附属医院ICU科,大理市671000,E-mail:ztl7897@126.com
【摘要】目的探讨早期免疫营养对重型颅脑损伤患者营养状况及免疫功能的影响,为重型颅脑损伤患
者营养支持治疗提供科学依据。方法采用随机数字法将60例重型颅脑损伤患者分为3组:对照组、早期营
养组及早期免渡营养组各20例。对照组米用传统营养方法,早期营养组采用肠外营养(PN)和肠内营养(EN)
序贯营养支持治疗,早期免疫营养组在早期营养的基础上每天给予谷酰胺10g。分别检测患者第1天、第7
天和第14天的总蛋白、白蛋白、转铁蛋白、免疫球蛋白、CD3、CD4'及CD8水平,进而对其检測结果进行相互
对比分析。结果总蛋白、白蛋白、CD4+、CD8、CD4/CD81、gG水平比较,早期免渡营养组>早期营养
组>对照组(P<0.05),且随治疗时间的延长升高越明显(P<0.05)。结论早期的免疫营养对改善重型顺脑
损伤患者营养状况及促进免疫功能的恢复具有重要的作用。
【关键词】颅脑损伤;肠内营养;肠外营养;免疫功能;谷氪酰胺
【中图分类号)R651.15【文献标识码】A【文章编号】0253-4304(2014)03-032-04
DOI:10.11675/j.isan.0253-4304.2014.03.16
Effect of Early Enteral Nutrition on Nutritional Status and
Immune Function in Patients with Severe Head Injury
ZOU Tian-lei, ZHAO Yong-mao
(Intensive Care i, Afiled Hs of Dali r Dali 671000, hin)
Abstract Objective To investigate the effect of early enteral nutrition on nutritional status and immune
function in patients with severe head injury, and to provide a scientific basis for nutritional support treatment in patients
with severe head njur Methods sing e method of random number, 60 patients with severe head injury were randomly
divided into 3 groups, control group, early nutrition group and early immume mutrition group, with 20 patients in each group
The control group was given the traditional nutrition, the early nutrition group was given sequential nutrition support
treatment of paren eral nutrition(PN and enteral nutrition(EN), the early immune nutrition roup was given glutamin
(10 g daily )based on the early nutrition. The patients were deteted for otal protein, albumin, transferrin, immunoglobulin
CD3 D4 and D " levels on the fist, seven h and fourteenth day, hen the results were analyzed. Results The level
of otal pro en, a um, DD CD, G of early mme ion oup were higher tan those of ea
nutrition grou which were i er than the con ols(Ptreatment time(P <0.05). Conclusion Early immune nutrition plays an important role in improving the recovery of
nutrition status and immune function in patients with severe head injury
Key words) Head injury; Enteral nutrition; Parenteral nutrition; Immune function; Glutamine
作者简介:邹天雷(1967~),女,本科,副主任医师,研究方向:急危重症监护。