超声引导下射频热疗联合适形放疗治疗肝癌的近远期疗效.pdf

丁蕾,等超声引导下射频热疗联合遁形放疗洽疗肝癌的近远期疔效
超声引导下射频热疗联合适形放疗治疗肝癌的近远期疗效
丁蔷',张振2,江广斌3
Short and long term effect of radiofrequency hyperthermia combined With ultrasound
guided conformal radiotherapy in treatment of liver cancer
Ding Lei, Zhang
nen
langon
Department of Functional Diagnosis enter; Depa men of Heaob Su ey, Be g Youn Hos d Fated to aiad Medical
University, Beijing 100069, China; 'Hubei Medical College, Hubei Shiyan 442000, China
Abstract) Objective: To study the short and long term effeet of radiofrequency hyperthermia combined with ultra-
sound -guided conformal radiotherapy in treatment of liver cancer. Methods: A total of 80 consecutives diagnosed as
liver cancer from March 2012 to March 2014 were individed randomly into control and experiment groups, each of 40
cases. The patients in control group received single ultrasound-guided conformal radiotherapy, the patients in experi-
ment group received radiofrequency hyperthermia combined with conformal radiotherapy, compare the short and lor
em f ts Results: The Bilirin, albumin and ALT, PT levels e ore treatment in the two groups were no statistical
dif erence(P>0.05 The Bilirubin, AIT, P levels after treatment were all lower and albumin was hi
cr in the two
groups and they in experiment group were significantly more improvements than control group(P<0.05). The total
efficacy rate in experiment group was significantly higher(P<0.05). The tutor recurrence rate and fatality rate after 6
months and one -year in experiment group were all significantly lower(P<0.05 Conclusion: Radiofrequency h
perthermia combined with conformal radiotherapy could greatly improve short and long term effects in patients with liv
er cancer.
Key words)ultrasound-guided radiofrequency hyperthermia, conformal radiotherapy, liver cancer, short and long
term ettect
Modern Oncology2016,24(01):0088-0091
摘要】目的:探讨超声引导下射频热疗联合适形放疗治疗肝癌的近远期疗效。方法;迕续收集我院2012
年3月至2014年3月收治的80例肝癌患者的临床资料,患者均经临床表现、影像、生化检査及病理确诊为原
发性肝瘺。该研究取得我院伦理委员会通过及患者、家属的知情同意权后,依据随机数字表法将患者分为对
照组和观察组,每组40例。对照组给予单纯适形放疗,观察组在对照组的基础上联合使用超声引导下射频热
,对两组患者近期及远期疗效进行比较和分析。结果:两组患者治疗前胆红素、白蛋白、ALT和PT水平比
较,差异均无统计学意义(P>0.05);治疗后两组忠者的胆红素、ALT和PT水平均降低,且试验组降低的更明
显,白蛋白水平均升高,且试验组升高的更明显,差异均有统计学意义(P<0.05)。观察组患者的总有效率显
著高于对照组,差异有统计学意义(P<0.05)。随访发现,观察组患者6个月和1年的肿瘤复发率及患者的
病死率均显著低于对照组,差异均有统计学意义(P<0.05)。结论:超声引导下射频热疗联合适形放疗治疗
肝癌近远期效果显著,有效降低了放疗对肝脏的损害,患者耐受度较高,提高了患者远期生存率。
【关键词射频热疗;适形放疗;肝癌;近远期疗效
中图分类号」R735.7【文献标识码】ADO1:10.3969/j.isn.1672-4992.2016.01.025
文章编号】1672-4992-(2016)01-0088-04
原发性肝癌的恶性程度较高,就诊时大多为中晚期,失
收稿日期】2015-(04-1
去了手术治疗的机会,且对放疗、化疗不敏感,使肝癌的病死
【修回日期)2015-07-08
率居高不下,给患者的生命健康产生严重影响。以往临床
【基金项目】湖北省教育厅科学研究计划项目(编号:Q20132106)
多采用保守方式对肝癌进行治疗,随着三维适形放疗技术的
【作者单位】1首都医科大学附属北京佑安医院功能诊断中心;2肝
产生和发展,被广泛应用于中晚期肝癌的治疗中,且被证实
胆外科中心,北京10009
湖北医药学院,湖北十堰442000
为一种安全、有效的治疗方式。相关研究指出,将射频热疗
【作者简介」丁蕾(1978-),女,北京人,医师,主要从事超声诊断
与适形放疗相结合,可有效提高肝癌的治疗效果。为深入
及介人治疗的研究。E-mail:ding7683@163.com
了解超声引导下射频热疗联合适形放疗治疗肝癌的近远期
【通讯作者】张振(1977-),男,北京人,医师,主要从事肝胆外科疗效,我院对80例肝癌患者给予分组治疗,现将报道如下。
研究工作。E-mail;zhangz7683@163.com
资料与方法